Volumen 52 #1 | Año 2015 Volver Indice
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  Correlation between Osteocalcin, Insulin Resistance, Insulin Sensitivity and Carbohydrate Metabolism in an Elderly Population with Metabolic Syndrome  
  Authors:   Musso C, Mingote E, Durante C, Brenta G, Gurfinkiel M, Fossati MP, Martínez M, Nepote A, Fretes O, Schurman L, Sedlinsky C, Faingold C  
  Introduction: In recent years there has been increasing evidence about the relationship between bone and energy metabolism. Osteocalcin is a non-collagenous bone matrix protein synthesized by osteoblasts that locally modulates bone mineralization and is traditionally used as a bone formation marker. Osteocalcin has been shown to have hormonal actions both in in vitro models and in experimental animals. This hormone has the property of regulating insulin secretion and insulin sensitivity as well as beta pancreatic cell proliferation.
Aim: To evaluate the existence of correlation between serum osteocalcin levels, insulin resistance and insulin sensitivity markers in an elderly population with metabolic syndrome.
Material and methods: Eighty-eight elderly patients were included in our prospective study (68 % women, mean age 73 ± 6 ; 32 % men, mean age 74 ± 6). They attended the outpatient Endocrinology and Metabolism service at Dr. César Milstein Hospital and met the International Diabetes Federation (IDF) criteria of metabolic syndrome.
Serum Osteocalcin, Glycated haemoglobin (HbA1c), HDL and Triglycerides (TG) were measured. QUICKI and TG/HDL index were calculated.
Results: Serum osteocalcin levels were positively associated with HDL (r = 0.213, p = 0.05) and QUICKI (r = 0.212, p = 0.05), and inversely associated with TG (r = -0.218, p < 0.05), TG/HDL index (r = -0.217, p < 0.05) and HbA1c (r = -0.253, p < 0.05).
Conclusions: Our study showed that in elderly patients with metabolic syndrome, reduced osteocalcin levels were associated with increased insulin sensitivity, decreased insulin resistance indexes and impaired metabolic control.

Rev Argent Endocrinol Metab 52:8-13, 2015
No financial conflicts of interest exist.
  Key words: osteocalcin, metabolic syndrome, insulin resistance, carbohydrate metabolism, elderly patients  
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